Relationship benefits students and studio owners in more than 50 countries globally

(COPPELL) – The International Sport Karate Association (ISKA) recently selected Mannatech (NASDAQ: MTEX) as its exclusive dietary supplement provider. The announcement was made at ISKA’s 37^th annual U.S. Open, which featured more than 3,000 of the top martial artists from 40 participating countries and will be nationally televised on ESPN2 tomorrow, July 23, at 9 p.m. ET/6 p.m. PT.

“For the first time in the 25-year history of ISKA, we are happy to announce our partnership with Mannatech and share it with our more than 28,000 studio owners,” said Cory Schafer, president of ISKA.

“Third party certification by reputable organizations means Mannatech products have achieved a very rare level of purity, safety and trust,” said Robert A. Sinnott, Ph.D., MNS, co-CEO and chief science officer of Mannatech. “Many of our products are already certified Kosher and certified for GMP compliance by NSF International, but we believe having products certified by the ISKA governing body confirms the benefits our supplements have for elite athletes and others who are very particular about what they put into their bodies.”

The partnership will allow various Mannatech products to carry the ‘ISKA Certified for Elite Athletes’ seal, as well as a proven business-building opportunity for all studio owners represented by ISKA.

Present at the U.S. Open in Orlando were elite martial arts practitioners and Team Mannatech^SM athletes Chip Townsend and Ben Parra[1] who each set world records.

“Because of the variety of products offered in stores today, students often get confused with what nutritional supplements to take,” said Townsend. “This partnership will take the guesswork out of the purchase because Mannatech products are developed with real food technology solutions and without any banned substances.”

Replay dates of the ISKA U.S. Open will air on ESPN2, August 19 and 22 at 9 p.m. ET/6 p.m. PT.

For more information about ISKA, visit www.ISKA.com. For more information about the partnership, Mannatech’s products or business opportunity, visit www.Mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.Mannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

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For every purchase on an automatic order containing Ambrotose® complex powder, Advanced Ambrotose® powder, MannaBears™ gummies, PhytoMatrix® caplets, PhytoBurst® nutritional chews or Optimal Support Packets, a donation of PhytoMatrix® bulk dietary supplement is provided through MannaRelief^† to children in need worldwide. Mannatech’s goal is to provide one million servings of this technologically advanced nutritional supplement to children through the Give for Real program.

“Millions of children die from malnutrition every year, and today’s international food aid relies heavily on enriched flour-based cereals that no longer meet the new minimum standards set by the World Health Organization for young children,” said Robert A. Sinnott, Ph.D., MNS, co-CEO and chief science officer of Mannatech. “Our Give for Real program is unique to the direct selling industry and allows the company and our independent sales Associates to donate to optimize nutrition across the globe.”

To launch the program, Dr. Sinnott and Mannatech Founder Sam Caster will embark on a road show across the country where they will visit with Associates and share details about how the new outreach program supports Mannatech’s business opportunity and its mission of giving.

Mannatech has a long history of giving to disaster relief victims around the globe through its support of MannaRelief and its quest to bring nutritional supplements to orphanages all over the world. In addition to the ‘donation-through-consumption’ program, the company will sponsor one child for a month for each guest that accompanies an Associate at the Give for Real road show meetings.

Mannatech’s Real Food Technology® solution-inspired products provide one of the best strategies for addressing this crisis because Mannatech’s products are developed from real food-sourced ingredients chosen from those scientifically proven to best benefit the human body.

Individuals interested in Mannatech’s products, exploring its business opportunity and the Give for Real program can learn more at mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.Mannatech.com.

^†MannaRelief is an independent, nonprofit organization. It is not owned or operated by Mannatech, Incorporated.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

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Mannatech filed a lawsuit against these five companies, as well as EvenBetterNow, LLC, Oasis Advanced Wellness, LLC, Roex, Inc., VDF FutureCeuticals, Inc., and Country Life, LLC, in March 2010 in the United States District Court for the Northern District of Texas, Dallas Division, alleging infringement of four of Mannatech’s patents (U.S. Patents 6,929,807; 7,157,431; 7,199,104; and 7,202,220). United States District Judge Reed O’Connor entered his judgments against these five companies in June. Judgments against EvenBetterNow and Oasis were previously entered in April.

“We are proud to obtain successful judgments against seven of the ten companies in this lawsuit and we intend to vigorously pursue our claims against the remaining defendants,” said Keith Clark, Mannatech executive vice president and chief legal officer. “This is a significant milestone for Mannatech in defending the strength and validity of our brand, products and patents.”

The court judgments all include broad injunctions that prohibit Micro Health Solutions, Wy’s Enterprises of Springfield, Florida Nutri Labs, Angel Care, USA, and New Sun from “making, using and offering to sell, selling, or otherwise distributing within the United States, or importing into the United States the infringing products as well as colorable imitations” as well as “providing assistance to others in making, using, offering to sell, selling, or otherwise distributing [infringing products] within the United States, or importing into the United States.”

Additionally, the judgments prohibit the five companies from supplying all or a substantial portion of the components of products that would infringe the patents in suit.

The previous judgments entered against EvenBetterNow and Oasis as well as these five judgments resolve the claims against seven of the ten companies that Mannatech recently filed a lawsuit against for infringing on its patents. Mannatech is represented by Eric Pinker, Mark Turk and Renee Strickland, with the Dallas-based litigation firm of Lynn Tillotson Pinker & Cox, LLP.

Mannatech has distinguished itself in the emerging glyconutrients market through the development of Ambrotose complex. Mannatech holds more than 45 patents in 30 countries for its Glyconutrient technology. Glyconutrients are dietary ingredients containing beneficial amounts of carbohydrates which are believed to represent a new category of untapped vital nutrients for proper nutrition.

Many of Mannatech’s products are based on Real Food Technology^SM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at mannatech.com.

About Mannatech

Mannatech, Incorporated develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, please visit www.mannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions

reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

###

(COPPELL, Texas) June 22, 2010 - Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness, and skin care solutions based on nutritional science, announced the results of a recent randomized, double-blind, placebo-controlled, crossover trial that investigated the effect of its reformulated creatine-free EM•PACT^® sports drink.   

When EM•PACT drink mix was first studied in 2006, the authors concluded that the Mannatech sports supplement could “provide meaningful practical applications for coaches and athletes regarding possible alternative hydration options” prior to aerobic workouts.[1] The published study was indexed by PubMed.gov, the medical literature search engine most commonly used by health care providers and sponsored by the U.S. Department of Health & Human Services’ National Institutes of Health.

Four years later, this new independent study shows that a single serving of a revised formulation of the EM•PACT sports drink provides the same benefits as the original formulation–enhancing indices of aerobic performance. The product significantly increased maximal oxygen consumption, time to exhaustion and percentage of estimated non-protein fat substrate utilization of the college students who took part in the study. Estimated non-protein substrate utilization in this study indicated that energy was obtained from the burning of fat, rather than carbohydrates within the muscle during exercise. Associate Professor of Kinesiology at Angelo State University Dr. Allyn Byars published both the 2006 and 2010 findings in the Journal of the International Society of Sports Nutrition.[2]

“This study performed by Dr. Byars, an expert in the field of exercise physiology, confirms that Mannatech’s creatine-free EM•PACT product, which meets the compliance standards of various athletic organizations that regulate the use of dietary supplements, is as effective as the original formulation,” said Robert A. Sinnott, MNS, Ph.D., co-chief executive officer and chief science officer of Mannatech. “The enhanced aerobic performance noted with the study participants shows that anyone interested in improving their athletic performance should consider including the EM•PACT product in their workout regimen.” *  

This study, funded by Mannatech, included 29 male and female college students who varied in levels of aerobic fitness. Dr. Byars performed a randomized crossover administration EM•PACT drink mix and placebo 30 minutes prior to performing a treadmill test with approximately one week separation between the trials in an effort to measure affects on maximal oxygen consumption and heart rate, time to exhaustion and the percentage of estimated non-protein fat substrate utilization. 

Its conclusion was the modified EM•PACT drink mix formulation utilized in this investigation supports the findings of the previous investigation and its efficacy for enhancing indices of aerobic performance (specifically maximal oxygen consumption, time to exhaustion and fat substrate) during graded exercise testing. 

“Placebo-controlled, human clinical studies such as this one from Dr. Byars are the gold standard in nutritional research. They validate Mannatech’s commitment to science and Real Food Technology^SM solutions,” said Sinnott. “As the pioneer of nutritional glycobiology and supporter of athletics globally, we will continue to be a leader in the field of validated sports nutrition.” 

The newly formulated creatine-free EM•PACT drink mix will be available from Mannatech in July. 

Many of Mannatech’s products are based on Real Food Technology solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body. Mannatech offers the best alternative to synthetic vitamin and mineral products and so-called “super-juice” products.

In 1994, Mannatech founded the Team Mannatech^SM program, a group of 195 athletes worldwide who utilize cutting-edge training techniques and proper nutrition while serving as educators preserving the integrity of sports competition and the health of all athletes. 

Athletes interested in learning more about the Team Mannatech program can visit www.teammannatech.com/. For more information about Mannatech’s scientific research and findings, visit www.mannatechscience.org/. Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at www.Mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.AllAboutMannatech.com. 

[1] This study consisted of 24 volunteers who performed two, one-hour oxygen consumption tests on motor-driven treadmills and 20 minutes prior, were given either a placebo or EM-PACT

[2] Byars A., et al., 3[1]:56 - 59, 2006; Byars A., Keith S., Simpson W., Mooneyhan A., Greenwood M: The influence of a pre-exercise sports drink (PRX) on factors related to maximal aerobic performance. J Int Soc Sports Nutr 2010, 7:1-6.

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 

(COPPELL, Texas) June 10, 2010 - Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness and skin care solutions based on nutritional science, announced that its shareholders passed all three proposals put to a vote at the company’s annual shareholder meeting held Wednesday, June 9, 2010.

Mannatech’s Co-CEO’s Dr. Robert Sinnott and Stephen Fenstermacher spoke to the shareholders and employees sharing the company’s accomplishments and perspective on 2009. Dr. Sinnott provided insight into the seven key strategic initiatives for the company for 2010.  Mr. Fenstermacher discussed the company’s results related to Mannatech’s operations for 2009 and for the first quarter of 2010. In addition, Mannatech’s President of International, Randy Bancino provided an update on next year’s entry into Mexico. Chairman of the Board J. Stanley Fredrick provided opening remarks.    

There were 26,489,388 outstanding shares of Mannatech’s common stock as of April 16, 2010 entitled to vote and 21,386,419 shares, or 80.7%, represented at the meeting, either in person or by proxy.

Shareholders voting in person or by proxy approved Mannatech’s proposal to elect J. Stanley Fredrick and Patricia A. Wier to its Board of Directors as Class II Directors. Each of the two nominees for director received, on average, approximately 76.8% of shares voted at the meeting.

Shareholders voting in person or by proxy and representing approximately 99.7% of shares voted at the meeting, ratified the appointment of Mannatech’s independent registered public accounting firm, BDO Seidman, LLP, for Mannatech’s fiscal year ended December 31, 2010.

Shareholders voting in person or by proxy and representing approximately 73.9% of shares voted at the meeting, approved amendments to the Mannatech, Incorporated 2008 Stock Incentive Plan to permit a one-time stock option exchange program which allows eligible option holders (including employees, officers and members of the Board of Directors) to exchange their “out of the money” stock options for fewer replacement options at a lower exercise price.

Mannatech has distinguished itself in the emerging glyconutrients market through the development of Ambrotose^® complex, the technology for which it holds more than 45 patents in 30 countries. Glyconutrients are dietary ingredients containing beneficial amounts of carbohydrates which are believed to represent a new category of untapped vital nutrients for proper nutrition.

Many of Mannatech’s products are based on Real Food Technology^SM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at www.mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care solutions that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.AllAboutMannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend”, “believe”, “expect” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s ability to attract and retain Associates and Members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

Contact Information:

Gary Spinell

Senior Vice President Finance & Administration

972-471-6512

ir@mannatech.com

www.mannatech.com

https://new.mannatech.com

www.allaboutmannatech.com

(COPPELL, Texas) May 25, 2010 -  Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness, and skin care solutions based on nutritional science, announced the results of an independent human clinical study that demonstrated intake of its proprietary Ambrotose AO^® capsules raised antioxidant protection in serum oxygen radical absorbance capacity (ORAC) in healthy adults, further validating a previous human study.* † 

The effect on serum ORAC, a method of measuring antioxidant capacities, was very similar between the two studies. The 2010 five-week study by Dr. Stephen P. Myers of 21 healthy adults by physicians and scientists from Australia and New Zealand showed that four capsules per day of Ambrotose AO dietary supplement was safe and raised ORAC by 36.6 percent.¹

The 2003 pilot study of 12 healthy adults by Dr. Stephen Boyd, Mannatech’s Senior Director, Medical Affairs, Mannatech scientists and an independent statistician showed that two capsules per day of Ambrotose AO capsules increased ORAC by 37.4 percent.²

“We are proud to have two human clinical studies that consistently show our Ambrotose AO product improves antioxidant status of human blood. These results demonstrate antioxidants in Ambrotose AO capsules provide the best antioxidant protection available today,” said Mannatech’s Co-CEO and Chief Science Officer Robert A. Sinnott, MNS, Ph.D.  “Antioxidants help reduce the amount of free radicals and oxidative stress that can damage or even kill cells. In addition to providing antioxidant support, many of the nutrients in Ambrotose AO capsules have been shown to promote a healthy immune system.”* † 

Mannatech’s Ambrotose AO capsules appear to be the most promising antioxidant supplement investigated to date. Ambrotose AO capsules increased human serum ORAC levels more than a number of well-known antioxidant foods and other commercial products: in food studies, increases in serum ORAC have been documented following ingestion of strawberries (14.4 percent increase) or spinach (28.5 percent increase)³, buckwheat honey (7 percent increase)⁴ or Concord grape juice (8 percent increase)⁵. In a placebo-controlled trial of healthy adults, a single 100g dose of wild blueberry powder significantly increased serum ORAC by up to 16 percent⁶ and a single 1.25g dose of vitamin C raised serum ORAC by 23 percent³. Additional studies of supplements designed to exert antioxidant benefits showed no effect on serum ORAC: a fruit-based antioxidant drink (MonaVie Active^®)^7,8. 

Professor Stephen Myers, Ph.D., BMed, ND is Director of the Australian Centre for Complementary Medicine Education and Research (ACCMER), a unique joint venture of the University of Queensland and Southern Cross University (SCU) and the NatMed-Research Unit, Research Cluster for Health and Wellbeing (NRU-RCHW), SCU, Lismore, AU. The study’s findings were published in the peer‐reviewed BMC Complementary and Alternative Medicine.  

Currently, Mannatech holds more than 45 patents in 30 countries for the technology related to Ambrotose complex. In addition, many of Mannatech’s products are based on Real Food Technology^SM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body. 

For technical information about Mannatech’s products and scientific research publications, visit http://www.mannatechscience.org/. Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at http://www.mannatech.com/.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.AllAboutMannatech.com.

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 

† Mannatech, Incorporated funded both studies and donated the Ambrotose products used in each study. 

1 Myers SP, Stevenson L, Cheras PA, et al. (2010) A forced titration study of the antioxidant and immunomodulatory effects of Ambrotose AO supplement. BMC Comp Alt Med 10, doi: 10.1186/1472-6882-10-16.

2 Boyd S, Gary K, Koepke, et al. (2003) An open-label pilot study of the antioxidant effect in healthy people of Ambrotose AO. GlycoScience & Nutrition 4:1-6.

3 Cao G, Russell RM, Lischner N, Prior RL: Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. J Nutr 1998, 128: 2383-2390.

4 Gheldof N, Wang XH, Engeseth NJ: Buckwheat honey increases serum antioxidant capacity in humans. J Agric Food Chem 2003, 51: 1500-1505.

5 O’Byrne DJ, Devaraj S, Grundy SM, Jialal I: Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr 2002, 76: 1367-1374.

6 Kay CD, Holub BJ: The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr 2002, 88: 389-398.

7 Jensen GS, Wu X, Patterson KM, Barnes J, Carter SG, Scherwitz L et al.: In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. J Agric Food Chem 2008, 56: 8326-8333.

8 MonaVie Active is a registered trademark of MONAVIE, LLC.

May 15, 2010

(COPPELL, Texas) May 5, 2010 - Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness and skin care solutions based on nutritional science, today reported a net loss of $2.8 million or $0.11 cents per diluted share for the first quarter ending March 31, 2010, compared to a net loss of $4.8 million or $0.18 cents per diluted share for the first quarter of 2009. The company reported an operating loss of $2.9 million compared to an operating loss of $5.7 million in the first quarter of 2009.  First quarter EBITDA⁽¹⁾ was $165,000 compared to a negative $4.0 million EBITDA for the first quarter of 2009.  

First quarter net sales for 2010 were $60.7 million, a decrease of 14.2%, compared to $70.7 million in the first quarter of 2009.  North American sales declined 23.0% to $32.2 million compared to $41.8 million in the first quarter of 2009. International sales of $28.5 million decreased 1.4% compared to $28.9 million in the first quarter of 2009. International sales showed significant gains in South Africa, Taiwan and Singapore compared to sales in the first quarter of 2009. 

Dr. Robert Sinnott, Co-CEO & chief science officer, commented, “Regaining sales momentum particularly in our North America market, is our immediate and primary goal.  To help achieve this objective we are taking a different approach than in previous years, by more efficiently targeting our incentive program dollars, including marketing and sales efforts on the core strength of our business. These resources will go to support our markets and Associates who show potential and demonstrate a strong desire and effort in driving on-going sales and recruiting.”  

Stephen Fenstermacher, Co-CEO & chief financial officer, added, “Over the past year, we have focused on positioning our cost of sales, commission costs and operating expenses at efficient levels. The results of this quarter again indicate the positive impact of our efforts. Now our challenge is to improve operating profit by building our finished products sales base. To do so, our incentive plan and other marketing programs are designed to support a balanced approach for Associates to grow their businesses.  By growing their businesses, Associates expand their potential to provide Mannatech’s products to people worldwide. To support them, we will open a meeting facility in South Africa in May, and we intend to launch operations in Mexico in the first quarter of 2011. International expansion is a significant priority for Mannatech in 2010 and beyond. “ 

New independent Associates and Members totaled 20,913 in the first quarter of 2010, compared to 36,462 in the first quarter of 2009.  Total independent Associate and Member count based on a 12-month trailing period was approximately 485,000 as of March 31, 2010 as compared to 527,000 as of March 31, 2009. 

Conference Call

Mannatech will hold a conference call and webcast to discuss this announcement with investors on Thursday, May 6, 2010 at 9:00 a.m. Central Daylight Time, 10:00 a.m. Eastern Daylight Time.  Investors may listen to the call by accessing Mannatech’s website at www.mannatech.com.

Mannatech has distinguished itself in the emerging glyconutrients market through the development of Ambrotose^® complex, the technology for which it holds more than 45 patents in 30 countries. Glyconutrients are dietary ingredients containing beneficial amounts of carbohydrates which are believed to represent a new category of untapped vital nutrients for proper nutrition. 

Many of Mannatech’s products are based on Real Food Technology^SM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at www.mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care solutions that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.AllAboutMannatech.com. 

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend”, “believe”, “expect” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s ability to attract and retain Associates and Members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

(amounts in thousands) Three months ended March 31, 2010 and 2009:

		2010			2009
Net loss	$	(2,781	)	$	(4,775	)
Interest (income) expense		29			(74	)
Income taxes benefit		-			(2,248	)
Depreciation and amortization		2,917			3,146
EBITDA	$	165		$	(3,951	)

Net Sales in Dollars and as a Percentage of Consolidated Net Sales - (Unaudited)

_________________________

⁽¹⁾ Austria, the Netherlands, Norway, and Sweden began operations in September 2009.

The number of new and continuing independent associates and members who purchased our packs or products during the twelve months ended March 31, 2010 and 2009 were as follows:

MANNATECH, INCORPORATED AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEETS

(in thousands, except share and per share amounts)

MANNATECH, INCORPORATED AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF OPERATIONS - (UNAUDITED)

(in thousands, except per share information)

(COPPELL, Texas) May 5, 2010 - Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness and skin care solutions based on nutritional science, today announced its plans to launch business operations in Mexico on Jan. 24, 2011.  

“Only Mannatech offers the dynamic combination of real scientifically validated products along with an award-winning compensation plan, and we are excited to partner with our independent sales Associates to bring the Mannatech opportunity to Mexico,” said Randy Bancino, president of Mannatech’s global business operations and expansion. “Our decision to enter Mexico is a strategic move and serves as a gateway to the Latin American market.”   

According to the Direct Selling Association, Mexico - and its population of 110 million people - is the sixth-largest direct selling market in the world. Currently, more than two million people living in Mexico are involved with direct sales creating more than $3.5 billion in revenue. 

“Since our founding in 1994, our philosophy has been to support people looking to change their lives through a personal commitment to healthy living and dedication to building a business. It will be an honor to offer these opportunities to the great country of Mexico,” said Robert A. Sinnott, MNS, Ph.D., co-CEO and chief science officer of Mannatech. “With more than 45 patents in 30 countries for the technology related to Ambrotose^® complex and an ongoing commitment to conduct clinical studies that demonstrate the efficacy of our products, validated science is at the core of who we are and what we do.” 

Since 2007, Mannatech has invested approximately $15.7 million in world-class research and development efforts. Mannatech pioneered the concept of Real Food Technology^SM solutions by combining cutting-edge science with food-sourced ingredients to create the most nutritionally beneficial products for the human body. 

“Mannatech offers real nutritional solutions to a Mexican market that is demanding substance over ‘hype’ and a real opportunity that can transcend the borders through our global seamless compensation plan,” said Al Bala, Mannatech’s senior vice president of global sales. “I am truly excited about our commitment to offer both short-term and long-term earning potential to a highly entrepreneurial culture.” 

Mannatech will also host a Cinco de Mayo event at its headquarters in Coppell on Wednesday, May 5, at 6 p.m. CDT, to celebrate the announcement of the Mexico launch plans. The event is open to Associates and a guest and will be broadcast on www.mannatechlive.com/. This is a great opportunity for Mannatech’s Associates around the world to hear the vision, participate in a bilingual opportunity meeting and be one of the first to see the new Mannatech Mexico website. 

For more information on Mannatech’s expansion plans into Mexico visit www.MexicoMannatech.com.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at mannatech.com.

About Mannatech

Mannatech, Incorporated develops high-quality health, weight and fitness, and skin care solutions that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit AllAboutMannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

(COPPELL, Texas) April 30, 2010 - Mannatech, Incorporated (NASDAQ: MTEX - News), a global pioneer in the development of high-quality health, weight and fitness and skin care solutions based on nutritional science, obtained Final Judgments in a lawsuit against EvenBetterNow, LLC, and Oasis Advanced Wellness, LLC (Oasis), prohibiting both companies from the manufacture, use or sale of products infringing Mannatech’s patents. 

Mannatech filed a lawsuit against EvenBetterNow, Oasis and five other companies in March 2010 in the United States District Court for the Northern District of Texas, Dallas Division, alleging infringement of four of Mannatech’s patents (U.S. Patents 6,929,807; 7,157,431; 7,199,104; and 7,202,220). United States District Judge Reed O’Connor entered his final judgments against the companies in April.

“We will continue to defend our proprietary Ambrotose product against companies that infringe our patents,” said Keith Clark, Mannatech’s executive vice president and chief legal officer. “These results continue to show the strength and validity of our patents and brand.” 

The final judgments include broad injunctions that prohibit EvenBetterNow and Oasis from “making, using and offering to sell, selling, or otherwise distributing within the United States, or importing into the United States the infringing products as well as colorable imitations” as well as “providing assistance to others in making, using, offering to sell, selling, or otherwise distributing within the United States, or importing into the United States.”

Additionally, the judgments prohibit EvenBetterNow and Oasis from supplying all or a substantial portion of the components of the infringing products that would infringe the patents in suit. 

The settlements with EvenBetterNow and Oasis resolve the claims against two of the seven companies that Mannatech recently filed a lawsuit against for infringing on its patents. Mannatech is represented by Eric Pinker, Mark Turk and Renee Strickland, with the Dallas-based litigation firm of Lynn Tillotson Pinker & Cox, LLP.

Mannatech has distinguished itself in the emerging glyconutrients market through the development of Ambrotose complex, the technology for which it holds more than 45 patents in 30 countries. Glyconutrients are dietary ingredients containing beneficial amounts of carbohydrates which are believed to represent a new category of untapped vital nutrients for proper nutrition. 

Many of Mannatech’s products are based on Real Food Technology^SM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at mannatech.com.

About Mannatech

Mannatech, Incorporated develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, please visit AllAboutMannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.